The goal of this study was to assess the levels of C-reactive protein (CRP) and interleukin 6 (IL-6) in women with uncomplicated term pregnancies before, during, and after labour as inflammatory contributing variables.
The research is conducted in a cross-sectional manner.
Between June 2019 and February 2020, the study was conducted at the Department of Obstetrics and Gynecology at Babcock University Teaching Hospital (BUTH) and the Department of Biochemistry at Babcock University in Ogun State, Nigeria.
Methodology: A total of 45 venous blood samples were collected from 34 women and divided into three groups: prenatal (32 weeks, n = 18), labour (4 to 6 cm dilation, n = 12), and postnatal (24 hours after delivery, n = 15). A total of sixteen blood samples were taken from the umbilical cord. CRP and IL-6 levels were measured using Enzyme Linked Immunosorbent Assay (ELISA) methods, and the leukocyte count was evaluated using a hematologic approach. One-way analysis of variance (ANOVA) with Bonferroni post hoc comparison was used to assess differences in statistical mean. The significance threshold was chosen at P 0.05.
The concentration of serum IL-6 during labour (1354.79 189.16 pg/mL) was substantially higher than during the prenatal (14.94 4.86 pg/mL, P.001) and postnatal (13.17 3.06 pg/mL, P.001) periods. The low level of CRP found during active labour did not achieve a meaningful difference when compared to the prenatal and postnatal periods. In the cord blood, the levels of these inflammatory markers were modest. During the postnatal period, leukocyte counts (P =.011), neutrophil counts (P =.014), and MID cell fractions (P =.004) were all considerably greater.
Conclusion: The high levels of serum IL-6 found in this investigation support the idea that human term labour is an inflammatory event without an increase in leukocytosis.
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