Aims: Malaria is a disease that kills a lot of people every year. Many investigations have been conducted to determine why malaria has remained endemic in particular areas since its inception. Some FCR polymorphisms appear to have an impact on malaria susceptibility. The goal of this study was to figure out how common specific FCR polymorphisms are and how they affect antibody production.

At Saponé, researchers conducted two cross-sectional surveys.

Sampling took place in Saponé during low (January 2007) and high (September 2007) malaria transmission seasons, with laboratory activities taking place at the Wenner-Gren Institute, Stockholm University, Sweden. Methodology: During each cross-sectional survey, 5 mL of venous blood was obtained from each kid in an EDTA-containing tube for antibody testing and FCR genotyping by PCR. For malaria microscopy diagnosis, thick and thin blood films were made from finger pricks.

The study enlisted the participation of 622 Mossi children. In pupation, three mutant alleles were found. FCGR2C (rs3933769), FCGR3A (rs396991), and FCGR2B (rs1050519) mutant allele frequencies are 15.43 percent, 66.24 percent, and 37.94 percent, respectively. In terms of SNPs, they play a role in malaria pathogenesis. Carriers of the mutant allele of FcRIIB (rs1050519) harboured significantly more parasites than non-carriers (P=.002). For all of them, however, mutant alleles of FCRIIC (rs3933769) and FCRIIIA (rs396991) harboured fewer parasites than wild alleles (P=.001). Total IgG responses are linked to SNPs. IgG responses were negatively related with the FCRIIB (rs 1050519) SNP (permutation of G to T). Children with the genotype GG (Wild type) generated higher antibodies against MSP3 than those with the alleles GT (Heterozygous) and TT (Triple Type) (Mutant). There was a statistically significant difference (P=0.05). The FcRIIB mutation, on the other hand, was linked to the generation of cytophilic IgG against MSP2B, GLURP R0, and GLURP R2. For MSP2A, the difference was statistically significant (P0.001). FCR2b, FCR2c, and FCR3a are all found in our study population. FCR mutations appear to influence malaria antibodies.

Please see the link :- https://www.journalaji.com/index.php/AJI/article/view/30144

 This free site is ad-supported. Learn more
​