PCOS (polycystic ovarian syndrome) is a prevalent endocrine condition that affects women of reproductive age. Some of the key risk factors for breast cancer include the hormonal profile and comorbidities prevalent in women with PCOS, such as obesity and diabetes. The goal of this study is to look at the possible link between PCOS and breast cancer. The epidemiological data, the relationship of PCOS-related symptoms and PCOS treatments with the incidence of breast cancer are the subject of this study.
Methodology: A systematic literature search was conducted using Ovid MEDLINE, Google Scholar, and PubMed to find epidemiologic studies that reported on the connection between PCOS and breast cancer published in the previous 10 years (from 2010 to June 25, 2020). Polycystic ovarian syndrome, breast cancer, and breast neoplasms were utilised as keywords.
The majority of epidemiological research found no evidence of a link between PCOS and breast cancer. Evidence suggests that high levels of androgen and oestrogen are linked to an increased risk of oestrogen receptor positive breast cancer. Obesity, hyperinsulinemia, and a low level of sex hormone binding globulin were also found to enhance the risk of breast cancer in women. Unlike metformin and clomiphene citrate, combined hormonal contraception is connected to an increased risk of breast cancer when used as a first-line therapy for PCOS.
Conclusion: Because the clinical data from this analysis are contradictory, a strong conclusion about the link between PCOS and breast cancer cannot be drawn, highlighting the need for further prospective research in the future.
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