The purpose of this study was to look into the antinociceptive properties of Picralima nitida stem bark methanol extract. From February to July 2020, in the Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.
Methodology: The pulverised P. nitida stem bark was cold macerated in 80 percent methanol for 48 hours to extract the active ingredient. The up and down approach was used in an acute toxicity investigation. Tail flick and hot plate antinociceptive models were used in the antinociceptive investigation. The extract was given at dosages of 100, 200, and 400 mg/kg, with pentazocine 3 mg/kg serving as the positive group's standard reference medication and 5 ml/kg distilled water serving as the negative group's.
P. nitida at doses of 100 and 400 mg/kg in combination with the standard drug pentazocine significantly (P = 0.05) increased the pain reaction time (PRT), increasing it from 1.80 0.08 sec in the negative group (distilled water 5 ml/kg) to 2.90 0.18 sec at the dose of 200 mg/kg group of mice, a 62.06 percent increase. In the hot plate paradigm, the PRT was enhanced from 2.03 0.02 sec in distilled water-treated mice to 9.58 0.99 sec in 400 mg/kg extract-treated animals.
Conclusion: In the models employed in this investigation, the stem bark methanol extract of P. nitida showed good antinociceptive action.
Please click here : https://journalijbcrr.com/index.php/IJBCRR/article/view/30217
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