A new application of Atomic Absorption Spectroscopy (AAS) was used to determine magnesium as an active component and/or excipient in its solid forms (effervescent and uncoated compressed tablets).
Methodology: The magnesium linear range was established. The researchers looked at a sample of magnesium effervescent pills. Two digestive procedures were used to evaluate the content of magnesium stearate in commercial paracetamol tablets. Finally, the impact of talc on the total magnesium content of a sample of drug-free tablets (only containing excipients) was investigated.
Linear range was seen in magnesium concentrations ranging from 0.08 to 0.40 ug/mL. The percentage of effervescent tablet samples recovered ranged from 98.66 to 103.00 percent, indicating that the product satisfies criteria. The average concentration of magnesium stearate in paracetamol tablets was 0.2 percent, with no differences between the two digestion techniques (t=0.454). In the presence of talc, we found a substantial rise in magnesium concentrations in the drug-free sample.
Conclusion: The AAS method is a simple and fast approach that may be used to estimate magnesium in both in-process and finished products analyses.
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