[New post] Oral Biomedical Applications of Chitosan
Conference Alerts posted: " Chitosan and chitosan derivatives have increasingly found application in the biomedical sciences. A review on the use of these materials in oral biomedicine has been published in the journal Polymers. Chitosan, which is produced by the deacetylati" European Conferences
Chitosan and chitosan derivatives have increasingly found application in the biomedical sciences. A review on the use of these materials in oral biomedicine has been published in the journal Polymers.
Chitosan, which is produced by the deacetylation of chitin, a biomolecule found extensively in crustacean and insect exoskeletons as well as the cell wall of microorganisms, is a highly attractive biomaterial. It possesses characteristics such as biocompatibility, non-toxicity, and biodegradability. This material is mucoadhesive, hemocompatible, and has potent antimicrobial and antioxidant properties.
Chitosan does not induce an immune response or inflammation in patients, but its low solubility in aqueous solutions limits its applications in living organisms. In recent years, there have been several studies exploring the potential of chitosan and chitosan derivatives in biomedical applications.
Drug delivery applications have been widely explored, and the role chitosan plays in coagulation by enabling reactions between platelets and amino groups has led to the development of chitosan-incorporated wound dressings. Wound dressings that utilize this biomaterial possess benefits such as chemoattraction, analgesic properties, antibacterial properties, hemostasis, limited scar formation, and neutrophil and macrophage activation.
In vitro and in vivo studies on chitosan and its derivatives have demonstrated potent antitumor activity in patients. Glucosamine and N-acetyl glucose are formed when chitosan and chitosan derivatives break down, and these products are non-toxic, easily excreted, and possess no immunogenicity.
The Study
The new paper, which has been contributed to by scientists from Korea, Saudi Arabia, and India, has provided a comprehensive review on current research perspectives in this field. The team has surveyed various novel chitosan derivatives used as drug delivery materials currently and have reviewed milestones in chitosan derivative use in oral drug delivery.
Based on the review of current biomedical applications, the authors have highlighted the lack of chitosan derivative use for oral drug delivery and discussed this in-depth. Reasons as to why this may be have been explored by the authors. Future perspectives have been highlighted, covering the potential of these highly attractive biomaterials in this vital area of oral biomedicine research. Nearly one hundred previous studies have been reviewed in the new paper.
Novel Chitosan Derivatives
Several novel chitosan derivatives have been developed in recent years. Modification processes such as deamination, nitration, photoactivation, N-acetylation, phosphorylation, and metal chelation are employed to synthesize various derivatives.
Classes of derivatives that have been researched for biomedical and oral biomedical applications include N-(Aminoalkyl) chitosan, Mitomycin C Conjugated N-succinyl chitosan, acetylated chitosan, and chitosan hydrochloride derivatives. Modifications to the chemical structure of derivatives enhance properties such as their unique biomedical characteristics, solubility, drug-releasing properties, and in situ gelling properties.
Oral Drug Delivery of Chitosan and Derivatives
The review has highlighted several recent advances in oral drug delivery using nano/microparticulate chitosan and chitosan derivatives. Chitosan's hydrophobicity and the swelling solution's pH influence drug release, and drug release mechanisms in chitosan drug delivery systems involve swelling, diffusion through the material's polymeric matrix, and erosion of the material.
There are many benefits to chitosan-mediated oral drug delivery systems. These include enhanced colloidal stability, active epithelial uptake, enhanced drug absorption, ability to open tight junctions, prolonged oral bioavailability, enhanced bioadhesion, and protection of labile drugs from enzymatic activities.
Several studies have investigated the benefits of chitosan-based drug delivery systems for oral biomedicine. For instance, they have been used to provide protection for orally taken insulin in the upper gastrointestinal tract. Cellulose acetate butyrate-coated chitosan spheres have been used to deliver 5-ASA for ulcerative colitis treatment. These important biomaterials have also been used for the oral delivery of therapeutic proteins and peptides.
Trimethyl chitosans have been studied for various oral drug delivery applications, including oral buserelin absorption. Liposome microspheres have been coated with trimethyl chitosans and chitosan-EDTA, with favorable results as drug delivery systems for insulin. Insulin-trimethyl chitosan polyelectrolyte complexes have displayed enhanced colloidal stability and protect insulin from degradation in studies using simulated intestinal fluid.
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