The goal of this study was to see if Hypoestes rosea could protect albino rats' livers from acetaminophen-induced damage.
The study is designed as a case-controlled interventional study.
Between June 2018 and December 2019, this study was undertaken in the Experimental Animal Unit of the Department of Human Physiology at the University of Port Harcourt.
The rats were separated into six experimental groups of extract control (EC), negative control (NC), positive control (PC), aqueous extract of Hypoestes rosea (AEHr) 100 mg/kg body weight (b w), AEHr 200 mg/kg b w., and AEHr 300 mg/kg b w., each of which had six rats. Each of the study groups had two treatment phases (Pre-treatment and Post-treatment phases), as well as two treatment durations (Acute and Sub-chronic) and six experimental groups in each phase.Blood samples were obtained through the jugular vein under chloroform anaesthesia in a desiccator at the conclusion of the research period for liver function measures. Total Bilirubin (TB), Conjugated Bilirubin (CB), Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline phosphatase (ALP), 5'-Nucleotidase (5'NT), Lactose Dehydrogenase (LDH), Gamma Glutamyl Transpeptidase (GGT), Total Protein (TP), and Albumin (ALB) Rat livers were also collected for histopathology research. SPSS version 23 was used for statistical analysis, and p0.05 was considered statistically significant.At the end of the study, blood samples were taken from the jugular vein under chloroform anaesthesia in a desiccator to assess liver function. Rat livers were also obtained for histopathology investigation. Total Bilirubin (TB), Conjugated Bilirubin (CB), Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline phosphatase (ALP), 5'-Nucleotidase (5'NT), Lactose Dehydrogenase (LDH), Gamma Glutamyl Transpeptidase (GGT For statistical analysis, SPSS version 23 was employed, and p0.05 was considered statistically significant.Conclusion: Acetaminophen-induced toxicity produced hepatotoxicity, which may lead to liver damage, and albino rats' ingestion of AEHr protected them against acetaminophen toxicity and probable liver damage. As a result, the findings of this study imply that Hypoestes rosea has hepatoprotective characteristics in albino rats and that more research, particularly in humans, is warranted.
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