[New post] Novel universal flu vaccine confers protection against different strains and subtypes of influenza A viruses
Conference Alerts posted: " A new universal flu vaccine constructed with key parts of the influenza virus offers broad cross protection against different strains and subtypes of influenza A viruses in young and aged populations, according to a new study by researchers in the Instit" European Conferences
A new universal flu vaccine constructed with key parts of the influenza virus offers broad cross protection against different strains and subtypes of influenza A viruses in young and aged populations, according to a new study by researchers in the Institute for Biomedical Sciences at Georgia State University.
The researchers developed the universal flu vaccine by genetically linking two highly conserved (relatively unchanged over time) portions of the virus – the extracellular domain of matrix 2 (M2e) and the stalk protein found in influenza A H3N2 viruses. The findings, published in the journal npj Vaccines, show that M2e-stalk protein vaccination induced broad protection against different influenza virus strains and subtypes by universal vaccine-mediated immunity in adult and aged mice.
The M2e-stalk protein, for the first time, could be easily produced in bacterial cell cultures at high yields and was found to confer protection against heterologous and heterosubtypic cross-group subtype viruses (H1N1, H5N1, H9N2, H3N2 and H7N9) at similar levels in adult and aged mice. These results provide evidence that M2e-stalk genetic fusion proteins can be produced in a large scale at low cost and developed as a universal influenza A virus vaccine candidate for young and aged populations." Dr. Sang-Moo Kang, senior author of the study and professor in the Institute for Biomedical Sciences at Georgia State
The study found this novel M2e-stalk protein vaccine induced M2e and stalk-specific Immunoglobulin G (IgG) antibodies that recognized antigenically diverse influenza viral antigens on virus particles and on the infected cell surface. In addition, the vaccine stimulated protective cellular T cell immunity and effective lung influenza viral clearance in mice.
Co-authors of the study include Jeeva Subbiah (first author), Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Bao-Zhong Wang and Sang-Moo Kang of the Institute for Biomedical Sciences at Georgia State; and Baik-Lin Seong of the College of Medicine and the Vaccine Innovative Technology Alliance (VITAL)-Korea at Yonsei University in the Republic of Korea.
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