The impact of Moringa oleifera aqueous extract on nephrotoxicity and liver damage caused by sodium chloride in Wistar albino rats was investigated. M. oleifera was collected from the Imo State University School farm and made into an extract, which was given orally to test rats in groups (III, IV, and V) versus experimental control rats (group II) who were only induced, as well as normal control rats (group I) who were not induced with sodium chloride and did not receive aqueous extract as treatment. In comparison to the experimental control rats, the percent weight change of test rats (groups III, IV, and V) showed a significant increase (p0.05) (group II). When compared to the normal control, the percent weight change in test rats rose insignificantly (p>0.05). When compared to the experimental control, urea and creatinine levels in test rats decreased substantially (p0.05), but rose significantly (p>0.05) when compared to the normal control. When compared to the experimental control, liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were considerably reduced (p0.05). The ameliorating effect reported in this study in test rats compared to experimental control rats might be due to M.oleifera extract. In the test rats, the extract may have had a protective effect against the severity of the generated sodium chloride. The preventive effect of M.oleifera aqueous extract on nephrotoxicity and liver damage caused by sodium chloride in Wistar albino rats was discovered in this investigation.
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