The goal of this study was to assess the anti-diabetic properties of Morus mesozygia. Leaf extrcts in Streptozotocin-Induced Diabetic Rats, Linn. Stapf.
The study is designed as an experimental case-control study.
Between June 2018 and April 2019, this study was conducted at the University of Port Harcourt's Biochemistry Research Laboratory in Rivers State, Nigeria.
The researchers employed a total of 65 male albino rats weighing between 150g and 200g for their investigation. Different groups of rats were given three different extracted solvents: aqueous, ethanolic, and methanolic leaf extracts. Male albino rats were induced for this investigation with a single dose of 40mg/kg b.wt streptozotocin intraperitoneally in 0.1M citrate buffer, pH 4.5. Male diabetic rats had fasting blood glucose (FBG) levels of 250 mg/dl or 13 mmol/L or higher.When compared to the values of the diabetic male rats treated orally with 200 mg/kg of MMLS, the results showed that there were significant decreases (p0.05) in FBG, increased insulin, increased C-peptide, and increased HOMA-IR concentrations in the diabetic male rats treated orally with 400 mg/kg of MMLS., and non-significant decreases (p0.05) in FBG, HOMA-IR, increased insulin, increased C-peptide concentrations in the diabetic male when compared to the levels of diabetic males who were given 200 mg/kg of methanolic leaf extracts of MMLS orally for 30 days. When compared to those who were given the conventional medicine metformin at a dose of 100mg/kg. When compared to the values in diabetic male rats treated orally with 400 mg/kg in dose of ethanolic and methanolic leaves extracts of MMLS., there was also a significant decrease (p0.05) in FBG, HOMA-IR, C-peptide, and increased insulin concentrations in diabetic male rats treated with 200 mg/kg in dose of ethanolic and methanolic leaves extracts of MMLS., when compared to the values in diabetic male rats treated orally.
Conclusion: We conclude that streptozotocin increased FBG levels, whereas the Methanolic, ethanolic, and aqueous extracts of Morus mesozygia Linn. S improved FBG, C-peptide, insulin, and HOMA levels in a dose-dependent manner, with the methanolic extract having the best ameliorative effect, likely due to its higher phytochemical composition.
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