The goal of this study was to assess the antioxidant and nephroprotective properties of Hypoestes rosea in albino rats exposed to acetaminophen intoxication.
The study is designed as a case-controlled interventional study.
Between June 2018 and December 2019, this study was undertaken in the Experimental Animal Unit of the Department of Human Physiology at the University of Port Harcourt.
The researchers employed a total of 112 adult albino rats weighing between 180 and 220 grammes for their investigation. Extract control (EC), negative control (NC), positive control (PC), aqueous extract of Hypoestes rosea (AEHr)100 mg/kg body weight (b w), AEHr 200 mg/kg b w., and AEHr 300 mg/kg b w. groups each included six rats. Blood samples for oxidative stress indicators (SOD & TAC) and renal function parameters (K+, Na+, Cl-, HCO3, urea & creatinine) were collected through the jugular vein under chloroform anaesthesia at the conclusion of the research period and evaluated using auto analyzers and spectrophotometric techniques. Rat kidneys were also removed for histological analysis.When comparing the PC group to the other experimental groups, the results showed that acetaminophen induced toxicity in albino rats caused oxidant-antioxidant imbalance and nephrotoxicity as evidenced by significantly (p0.05) reduced SOD and TAC from the oxidative stress parameters and elevated K+, urea & creatinine and reduced HCO3- from the renal function parameters. However, different doses of aqueous extract of Hypoestes rosea were able to restore the damage induced by acetaminophen induction to normal in a dose-dependent manner during different treatment stages in the acute and sub-chronic period. This was also validated by the experimental group's histology analysis.Conclusion: Acetaminophen-induced toxicity creates an oxidant–antioxidant imbalance and nephrotoxicity, both of which can lead to kidney damage, and albino rats' ingestion of AEHr protects them against acetaminophen toxicity and potential kidney damage. As a result of the findings of this in vitro investigation, Hypoestes rosea may have antioxidant and nephroprotective characteristics and should be studied in larger animals.
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